Police and emergency services are investigating a shooting in Prahran on Sunday morning.

Investigators believe multiple people were shot outside a night club near Little Chapel Street and Malvern Road about 3.20am.

Four people have been transported to hospital.

A 28-year-old man and a yet to be identified man are both critical.

A 50-year-old man and a 29-year-old man have both sustained non-life threatening injuries.

An investigation is underway and the exact circumstances are still being established.

Police are urging people to avoid the area and that anyone with information or footage of the incident to contact Crime Stoppers on 1800 333 000 or alternatively make a confidential report online at