The Argentine manager arrives from coaching Chilean side O’Higgins. He served as Marcelo Bielsa’s assistant for Chile in the 2010 World Cup.
Berizzo played for Celta from 2001-05, helping it reach the Champions League in 2003 and the final of the Copa del Rey in 2001. He also played for River Plate and Marseille.
Enrique, 44, a former Barcelona player who has coached the club’s B-team, said last week that he would not be continuing at Celta Vigo, a team he coached to a mid-table position this season.