A total of 836,954 infectious disease cases were reported last month, Xinhua quoted the commission as saying in a statement.
No cases of Class-A infectious diseases were reported. Plague and cholera are categorised as Class A, the most serious category.
About 325,953 cases of Class B infectious diseases were reported, resulting in 1,207 deaths. Hepatitis, tuberculosis, syphilis, dysentery and gonorrhea accounted for 93 percent of the cases in this category, the official statement said.
It said that category C infectious diseases claimed 74 lives in April, with foot-and-mouth disease, infectious diarrhoea and mumps reported most frequently.